The skill set of a paramedic varies by jurisdiction and may include monitoring and interperting electrocardiograms (EKGs), inserting intravenous lines, performing endotracheal intubation (a breathing tube into the lungs), and defibrillation. Paramedics administer a variety of emergency medications, ranging from calcium channel blockers that slow the heart rate to sympathomimetics like dopamine for severe hypotension (low blood pressure). They may also administer elective medications such as those which relieve pain or decrease nausea and vomiting.

Unlike most other health care providers, paramedics provide care that is not directly supervised by physicians. Rather, paramedics provide care under protocols written by physicians, which guide clinical decisions. In certain cases, paramedics in the field may contact an emergency physician to seek permission to perform certain uncommon procedures, administer certain medications, or discuss the appropriate treatment for a complicated situation.