James Ryley, Ph.D., RPA
Patents Online, LLC
As a Registered Patent Agent and the Founder of the most?visited patent searching site on the internet
As a Registered Patent Agent and the Founder of the most?visited patent searching site on the internet (www.FreePatentsOnline.com), I have a high degree of expertise in patent searching, patent prosecution, and the intricacies of enterprise?level search engine and web site design. Holding a PhD in molecular biology, I am also fairly well?versed in many other areas of technology and have a personal interest in computer science and nanotechnology.
I would be happy to serve as an Expert Witness in cases involving any of my areas of expertise, but I believe that the confluence of my subject matter expertise with my knowledge of patent law and procedure would make my testimony most valuable in cases involving the validity/invalidity of technology?based patent claims. I have an interest in patent claims construction and am also available to consult pre?trial for court cases or Board of Patent Appeals and Interferences hearings.
Intellectual Property Search and Analytics, Patent Prosecution, Biotechnology, Search Engine and Web Site Design
President at SumoBrain / Patents Online, LLC
January 2004 –Present
SumoBrain develops federated search technology and analytics for corporations and national patent offices. With an emphasis on saving time through single?point comprehensive search and analysis of intellectual property, scientific and financial data, SumoBrain's search software can simultaneously search world patent collections, internal corporate data, and various technical and business document collections such as NIH's PubMed and the SEC's EDGAR.
SumoBrain also offers an analytics platform, CobaltIP, which provides advanced graphing and charting for purposes such as patent searching, white space analysis, and competitive intelligence.
President at Patent Complete, LLC
Patent searching services, specializing in complex, technology?related searches requiring post?graduate subject matter expertise in fields ranging from biotech to physics and electrical engineering.
Making Searching Faster and More Complete: Cross?Collection Search and Automated Result Set Analysis
ICIC 2011, Conference Proceedings October 2011 Authors: James Ryley, Ph.D., RPA
Advanced document retrieval techniques for patent research
World Patent Information (Elsevier) December 2008
Latent semantic indexing (LSI) can be used in patent searching to overcome drawbacks of Boolean searching and to give more accurate retrieval. LSI combines the vector space model (VSM) of document retrieval with single value decomposition (SVD), using linear algebra techniques to uncover word relationships in the text. Results can be enhanced by using text clustering and tailoring SVD parameters to the specific corpus, in this case, patents, and by employing techniques to address ambiguities in language.
Next?Generation Patent Searching
PIUG 2007, Conference Proceedings May 2007 Authors: James Ryley, Ph.D., RPA
Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae
Yeast (John Wiley & Sons, Ltd.) August 2006
We have measured single?cell gene expression over time using a microfluidics?based flow cell which physically traps individual yeast using μm?sized structures (yeast jails). Our goal was to determine variability of gene expression within a cell over time, as well as variability between individual cells. In our flow cell system, yeast jails are fabricated out of PDMS and gene expression is visualized using fluorescently tagged proteins of interest. Previously, single?cell yeast work has been done using micromanipulation on agar, or FACS. In the present device agar is eliminated, resulting in a superior optical system. The flow of media through the flow cell washes daughter cells away, eliminating the need for micromanipulation. Unlike FACS, the described device can track individual yeast over a time course of many hours. The flow cells are compatible with the needs of quantitative fluorescence microscopy, and allow simultaneous measurements to be done on a large number of individual yeast. We used these flow cells to determine the expression of HSP104?GFPand RAS2?YFP, genes known to
affect yeast life span. The results demonstrate inter?cell variation in expression of both genes that could not have been detected without this single?cell analysis.
A Better Patent Search Engine: Latent Semantic Analysis for Patent Searching
PIUG 2006, Conference Proceedings May 2006 Authors: James Ryley, Ph.D., RPA
Using Conceptual Search in Scientific, Financial and Intellectual Property Databases
ICIC 2009, Conference Proceedings October 2009
Registered Patent Agent
United States Patent & Trademark Office License 68,868
The University of Texas Health Science Center at San Antonio
Ph.D., Molecular Biology
University of Maryland College Park
B.S., Cellular & Molecular Biology, Genetics